The Carcinostatic Activity of 5-Hydroxy-2-formylpyridine

نویسندگان

  • Erwin J. Blanz
  • Frederic A. French
چکیده

5 -Hydroxy-2-formylpyridine thiosemicarbazone (5-HP) is highly active intraperitoneally against leukemia L-1210, Ehrlich ascites carcinoma, and lymphoma L-5 178Y over a broad dose range. 5-HP is also active on leukemia L-l210 and the Ehrlich ascites carcinoma by delayed treatment. Activity by oral routes or subcutaneously is poor. Moderate activity is displayed against the Lewis lung carcinoma and adenocarcin oma 755 . 5-lIP is the most active antileukemic agent in this series to date.

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تاریخ انتشار 2006